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茶碱的安全范围窄,且是强效腺苷受体激动剂,若血浆浓度超过治疗剂量(>20mg/L),可引起心律失常和中枢神经系统兴奋症状,导致癫病发作、全身抽搐甚至致死。恩丙茶碱(Enprophylline)是一种有扩支气管作用的黄嘌呤类药,本文对两药的作用进行比较。用两种剂量的恩丙茶碱(1.5mg/kg和2.5mg/kg)与标准剂量的茶碱(3.0mg/kg),对63例急需治疗的哮喘患者作随机、双盲、平行分组试验,并比较疗效。在20分钟内静脉给药。检测给药前后的最大呼吸流率(PEFR)、心率、血压、动脉、血气、药物在血
Theophylline has a narrow safety range and is potent adenosine receptor agonist. If the plasma concentration exceeds the therapeutic dose (> 20 mg / L), it can cause arrhythmia and central nervous system irritation, leading to epilepsy attacks, generalized convulsions and even lethal. Enprophylline is a xanthine that has bronchodilatory effects. This article compares the effects of both drugs. Sixty-three asthmatic patients in urgent need of treatment were randomized, double-blind, and parallel-grouped with two doses of nalipheme (1.5 and 2.5 mg / kg) and a standard dose of theophylline , And more effective. Intravenous administration within 20 minutes. Before and after treatment to detect the maximum respiratory flow rate (PEFR), heart rate, blood pressure, arteries, blood gas, drugs in the blood