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目的:分析医院阴沟肠杆菌感染的临床分布及耐药性,以指导临床合理用药。方法:对医院近3年分离出的阴沟肠杆菌的临床分布特点及耐药情况进行总结分析。结果:2005年1月~2008年4月共分离出156株阴沟肠杆菌,菌株来源主要为痰液、尿液,分别占42.9%、23.7%。药物敏感性试验显示,阴沟肠杆菌对β内酰胺类抗生素显示较高耐药;对氨基糖苷、喹诺酮类等也有不同程度的耐药,对碳青霉烯类有很高的抗菌活性。结论:阴沟肠杆菌主要引起呼吸道、尿路感染;对三代头孢菌素耐药严重,呈多药耐药性,亚胺培南仍为治疗阴沟肠杆菌严重感染的首选用药。
Objective: To analyze the clinical distribution and drug resistance of Enterobacter cloacae infection in hospitals so as to guide clinical rational drug use. Methods: The clinical distribution characteristics and drug resistance of Enterobacter cloacae isolated in the past three years were summarized. Results: From January 2005 to April 2008, 156 strains of Enterobacter cloacae were isolated. The main sources of the strains were sputum and urine, accounting for 42.9% and 23.7% respectively. Drug susceptibility tests showed that Enterobacter cloacae showed high resistance to β-lactam antibiotics, resistance to aminoglycosides and quinolones, and antibacterial activity to carbapenems. Conclusion: Enterobacter cloacae mainly causes respiratory tract and urinary tract infections. The third generation cephalosporins are highly drug resistant and multi-drug resistant. Imipenem is still the first choice for the treatment of severe infections of Enterobacter cloacae.