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目的了解2016年开滦某矿在册人员乙型肝炎病毒(HBV)的感染情况,掌握流行规律,为进一步制定HBV的预防和控制措施提供科学依据。方法采用酶联免疫吸附测定法(ELISA)检测3 769名(20~82岁)受检者HBV血清学标志物(HBsAg、HBsAb、HBeAg、HBeAb、HBcAb),同时分析其HBV病毒携带情况、抗体产生情况以及HBV感染血清学反应模式。结果 3 769名受检者中,HBsAg、HBsAb、HBeAg、HBeAb、HBcAb阳性率分别为2.07%、32.98%、0.29%、2.73%和3.40%,全阴性检测率为64.74%。共检出8种反应模式,检出HBV感染者78人,HBV总感染率为2.07%。男性HBsAg携带率高于女性,但差异无统计学意义(χ~2=2.956,P>0.05)。其中,女性“2”模式(单纯HBsAb阳性)高于男性(χ~2=6.122,P<0.05),“全阴”模式低于男性(χ~2=4.663,P<0.05),其余模式性别差异无统计学意义。结论该人群的HBsAg阳性率显著低于全国平均水平,乙型肝炎三系全阴性检测率较高。而且仅1/3的人获得HBsAb,表明该人群免疫屏障并不完善,因此,应加强对该人群的HBV血清标志物检测和乙型肝炎疫苗的接种力度。
Objective To understand the status of Hepatitis B virus (HBV) infection among registered cadres in a mine in Kailuan in 2016 and to grasp the epidemic rules and provide a scientific basis for the further development of HBV prevention and control measures. Methods HBV serological markers (HBsAg, HBsAb, HBeAg, HBeAb and HBcAb) were detected in 3 769 subjects (20-82 years old) by enzyme-linked immunosorbent assay (ELISA) Occurrence and HBV infection serological response patterns. Results Among 3 769 subjects, the positive rates of HBsAg, HBsAb, HBeAg, HBeAb and HBcAb were 2.07%, 32.98%, 0.29%, 2.73% and 3.40%, respectively. The detection rate of all negative was 64.74%. A total of eight reaction patterns were detected, 78 were detected HBV infection, the total HBV infection rate was 2.07%. The carrying rate of HBsAg in males was higher than that in females, but the difference was not statistically significant (χ ~ 2 = 2.956, P> 0.05). The pattern of female “2” (HBsAb positive) was higher than that of male (χ ~ 2 = 6.122, P <0.05) , The rest of the gender differences were not statistically significant. Conclusion The positive rate of HBsAg in this population is significantly lower than the national average, and the detection rate of all three-line all-negative hepatitis B is high. And only 1/3 of the people get HBsAb, indicating that the population is not perfect immune barrier, therefore, should be strengthened in this population of HBV serum markers and hepatitis B vaccine inoculation.