目的评价圣.约翰草提取物治疗抑郁症的临床疗效和安全性。方法78例抑郁症患者随机分为2组,分别给予圣.约翰草提取物(路优泰)和盐酸阿米替林治疗,疗程8周。采用汉密顿抑郁量表(HAMD),汉密顿焦虑量表(HAMA),临床总体评定量表(CGI)评定临床疗效,不良反应评价用副反应量表(TESS)、实验室检查及体检。结果经8周治疗,圣.约翰草提取物组有效率为85.37%,阿米替林组为89.19%,两组比较差异无统计学意义(P>0.05)。圣.约翰草提取物抗焦虑症状的疗效明显优于阿米替林(P<0.01),不良反应轻微。结论圣.约翰草提取物是一种安全、有效、具有较好抗焦虑作用的抗抑郁剂。 Objective To evaluate the efficacy and safety of St. John’s wort extract in the treatment of depression. Methods Seventy-eight patients with depression were randomly divided into two groups. They were treated with St. John’s Wort extract (Lu Youtai) and amitriptyline hydrochloride for 8 weeks. The HAMD, HAMA, and CGI were used to assess clinical efficacy, TESS, laboratory tests, and physical examinations were used to evaluate adverse reactions. . Results After 8 weeks of treatment, the effective rate of St. John’s Wort extract group was 85.37%, and that of amitriptyline group was 89.19%. There was no significant difference between the two groups (P>0.05). The efficacy of St. John’s Wort extract was significantly better than that of amitriptyline (P<0.01). The adverse reactions were mild. Conclusion St. John’s Wort extract is a safe, effective anti-depressant with good anti-anxiety effect.