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目的：观察≤５μｍ和≥１０μｍ两组石棉纤维在作用时间和作用剂量上对豚鼠肺泡巨噬细胞生物学效应的关系。方法：采用细胞体外研究方法。结果：细胞死亡率，乳酸脱氢酶活性均随孵育时间延长及作用剂量的增大而毒性亦增加；细胞内钾离子含量则随时间的延长、剂量的增大而浓度降低。结论：结果证明两组石棉纤维均具有明显的细胞毒性作用。
OBJECTIVE: To observe the relationship between the biological effects of alveolar macrophages in guinea pigs with asbestos fibers at ≤5μm and ≥10μm on the action time and dosage. Methods: Using cell in vitro research methods. Results: The cell death rate and lactate dehydrogenase activity increased with the increase of incubation time and dose, but also increased with the increase of dose and concentration of potassium ion. Conclusion: The results show that both asbestos fibers have obvious cytotoxicity.