目的探讨新型隐球菌性脑膜炎的临床特点及影响预后的危险因素。方法对47例新型隐球菌性脑膜炎患者的临床资料进行回顾性分析。结果 47例患者中存在基础疾病者35例;从入院到确诊所需时间1 d～27周;37例误诊;37例脑脊液墨汁染色阳性,26例乳胶凝集试验全部阳性;颅内压显著增高≥350 mm H2O者25例。结论发现病程≥3个月、基础疾病≥3种、颅压≥400 mm H2O、出现意识障碍或脑积水者预后不良。 Objective To investigate the clinical features of cryptococcal meningitis and risk factors for prognosis. Methods The clinical data of 47 patients with cryptococcal meningitis were retrospectively analyzed. Results There were 35 patients with underlying diseases in 47 patients. The time from admission to diagnosis was 1 to 27 weeks, 37 were misdiagnosed, 37 were cerebrospinal fluid ink stain positive, 26 were latex agglutination test positive, and intracranial pressure was significantly increased ≥ 25 cases of 350 mm H2O. Conclusion It is found that the duration of disease is more than 3 months, the underlying diseases are more than 3, the intracranial pressure is ≥400 mm H2O, and the patients with unconsciousness or hydrocephalus have poor prognosis.