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为探讨肝细胞癌变过程中γ－谷氨酰移换酶（ＧＧＴ）和总ＲＮＡ的表达与动态改变，以０．０５％的２－乙酰氨基芴（２－ＦＡＡ）诱导ＳＤ大鼠肝癌发生，观察鼠肝在癌变过程中的组织学改变及总ＲＮＡ浓度和ＧＧＴ比活性的动态改变。结果表明，大鼠摄入２－ＦＡＡ后，鼠肝大量表达出ＧＧＴ，并引起血中ＧＧＴ活性异常；实验组血清总ＧＧＴ、肝组织可溶性及膜结合性ＧＧＴ均显著高于对照组（Ｐ＜０．０１）；６周后肝组织总ＲＮＡ浓度，较６周前显著升高（Ｐ＜０．０５），且与ＧＧＴ活性呈正相关（ｒ＝０．９０，Ｐ＜０．０５）。研究结果提示，ＧＧＴ为反映肝细胞癌变的标志酶，分析其活性有助于肝癌的早期诊断。
In order to investigate the expression and dynamic changes of γ-glutamyl transferase (GGT) and total RNA during hepatocarcinogenesis, SD rats were induced with 0.05% 2-acetylaminostilbene (2-FAA). Observe the histological changes and the dynamic changes of total RNA concentration and GGT specific activity of rat liver during carcinogenesis. The results showed that after rats ingested 2-FAA, a large amount of GGT was expressed in the liver of mice, and GGT activity in the blood was abnormal. The total serum GGT, liver tissue soluble and membrane-bound GGT were significantly higher in the experimental group than in the control group (P< 0.01); 6 weeks after the total RNA concentration in liver tissue was significantly higher than 6 weeks ago (P <0.05), and a positive correlation with GGT activity (r = 0.90, P <0.05). The results of the study suggest that GGT is a marker enzyme that reflects hepatocellular carcinogenesis and analysis of its activity contributes to the early diagnosis of liver cancer.