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目的:观察冠脉造影对糖尿病患者胱抑素C(CysC)和肾功能的影响,探讨造影剂肾病(CIN)发生的危险因素及其防治方法。方法:选取在我院行冠状动脉造影术患者78例,分为糖尿病组42例,对照组36例,于造影术前及术后第1,2,7天检测血清胱抑素C和肾功能。结果:糖尿病患者造影术后1d血CysC明显升高,与术前相比有统计学意义(P<0.05)。78例患者中发生CIN10例,其中糖尿病组8例,发生率为19.0%,对照组2例,发生率为5.6%。结论:冠脉造影可引起一过性肾损害,糖尿病是冠脉造影的危险因素。
Objective: To observe the effect of coronary angiography on cystatin C (CysC) and renal function in diabetic patients and to explore the risk factors of CIN and its prevention and treatment. Methods: Totally 78 patients undergoing coronary angiography in our hospital were divided into diabetic group (n = 42) and control group (n = 36). Serum levels of cystatin C and renal function were measured before and after operation on the 1st, . Results: The levels of CysC in diabetic patients at 1 day after operation were significantly higher than those before operation (P <0.05). Among 78 patients, CIN was found in 10 cases, including 8 cases of diabetes mellitus (19.0%) and 2 cases of control group (5.6%). Conclusion: Coronary angiography can cause transient renal damage. Diabetes is a risk factor for coronary angiography.