目的　研究长期大量吸烟对人心血管功能的影响。方法　对吸烟龄为 ( 2 3± 5 )年的 2 0个健康人进行了检测。每一个吸烟者均有一个性别、年龄和体重相近的未吸烟的健康人作为对照。在试验过程中 ,连续记录被检测者的心率和血压。结果　与对照组相比 ,吸烟者具有 :( 1)进行剧烈的Valsalva动作时 ,心率加快较少 (P <0 5 )。 ( 2 )Valsalva动作后动脉血压上升收缩压P <0 .0 1,舒张压P <0 .0 5。 ( 3)Valsalva动作后心率恢复到正常的时间较长 (P <0 .0 1)。 ( 4 )Valsalva动作后血压恢复到正常的时间较长 (P <0 .0 1)。以上结果表明 ,血压反射的减弱是由于长期的外周血管收缩的结果 ,而心跳反射减弱的结果是由于血压反射减弱的结果。这种反射时间的延长可能是副交感压力反射改变的一种表现。结论　长期大量吸烟者可伴有心血管自主神经支配的障碍 Objective To study the effect of long-term smoking on cardiovascular function. Methods Twenty healthy subjects with a smoking age of (23 ± 5) years were tested. Each smoker had a non-smoker healthy person of similar sex, age and weight as a control. During the test, the heart rate and blood pressure of the test subjects were recorded continuously. Results Compared with the control group, smokers had: (1) heart rate accelerated less during severe Valsalva (P <0.05). (2) Arterial blood pressure increased systolic pressure after Valsalva motion (P <0.01), diastolic blood pressure (P <0.05). (3) Heart rate returned to normal after Valsalva movement for a long time (P <0.01). (4) Blood pressure returned to normal after Valsalva action for a long time (P <0.01). The above results show that the decrease of blood pressure reflex is due to long-term peripheral vasoconstriction, and the result of the decrease of heart reflex is the result of weakened blood pressure reflex. This prolonged reflex may be a manifestation of changes in parasympathetic pressure reflex. Conclusion Long-term mass smokers may be associated with cardiovascular autonomic dysfunction