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目的和方法：本文采用人妊娠６～８周胎盘组织块的体外培养方法，通过检测干扰素免疫活性和抗病毒活性研究肿瘤坏死因子α（ＴＮＦα）对人滋养层干扰素（ＩＦＮ）分泌的影响。结果：ＴＮＦα可显著促进人滋养层ＩＦＮα的分泌，并呈剂量和时间依赖关系。同时各浓度的ＴＮＦα还可促进βＨＣＧ的分泌，并呈一定的剂量依赖关系。此外，我们还证明ＩＮＦα可显著抑制人滋养层细胞的生长，而ＴＮＦα则无明显作用。结论：ＴＮＦα可通过促进人滋养层干素α和βＨＣＧ的分泌，从而影响人胎盘的功能活动
Objective and Methods: In this study, the human placental tissue from 6 to 8 weeks of pregnancy in vitro culture methods to detect interferon immunological activity and antiviral activity of tumor necrosis factor α (TNFα) on human trophoblast interferon (IFN) secretion . Results: TNFα significantly promoted the secretion of IFNα from human trophoblast cells in a time-and dose-dependent manner. At the same time the concentration of TNFα can also promote the secretion of β HCG, and showed a dose-dependent relationship. In addition, we also demonstrated that INFα significantly inhibited the growth of human trophoblast cells, whereas TNFα had no significant effect. CONCLUSION: TNFα can affect the functional activity of human placenta through promoting the secretion of α and β HCG from human trophoblast