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目的 观察急性脑梗死患者血浆 β 内啡肽变化和纳洛酮的治疗效果。 方法 将我院 1999年 6月～ 2 0 0 0年 12月住院的 98例急性脑梗死患者分成两组 ,治疗前后分别采取空腹静脉血 2ml,用放免法检测β EP的含量 ,同时对患者的神经系统功能缺失进行评分 ,评价临床疗效。 结果 (1)治疗组总有效率89.5 8% ,对照组总有效率 5 8% ,治疗组的疗效明显高于对照组 (P <0 .0 1)。(2 )急性期 2组患者血浆 β 内啡肽均升高 ,随着临床症状的好转 ,β EP含量均有明显下降 ,治疗组下降更为明显 (P <0 .0 1)。结论 纳洛酮应早期应用 ,其作用迅速、疗效好 ,价格低廉 ,且无不良反应。
Objective To observe the changes of plasma β-endorphin in patients with acute cerebral infarction and the therapeutic effect of naloxone. Methods 98 cases of acute cerebral infarction hospitalized in our hospital from June 1999 to December 2000 were divided into two groups. Before and after treatment, 2 ml of fasting venous blood was taken and the content of β EP was detected by radioimmunoassay. At the same time, Neurological deficits were scored to evaluate the clinical efficacy. Results (1) The total effective rate was 89.5% in the treatment group and 58% in the control group. The curative effect of the treatment group was significantly higher than that of the control group (P <0.01). (2) The levels of plasma β-endorphin in both groups were increased in acute phase. The levels of β-EP were significantly decreased with the improvement of clinical symptoms, the treatment group decreased more significantly (P <0.01). Conclusion Naloxone should be used early, its rapid effect, good efficacy, low prices, and no adverse reactions.