目的 :探讨硫酸镁辅助治疗顽固性癫的剂量、方法及疗效。方法 :治疗组 72例 ,用 2 5 %硫酸镁 10mL静脉滴注 ,或用 16.5 %硫酸镁 10mL口服。对照组 3 6例给予常规抗癫药物 ,卡马西平或苯妥英钠加苯巴比妥或氯硝西泮加用γ 氨基丁酸等治疗。结果 :治疗组有效率 87.5 % ,对照组有效率 44.4% ,两组比较经统计学分析P <0 .0 1,差异极显著。结论 :硫酸镁联合一线抗癫药治疗顽固性癫的方法简单易行 ,具有良好效果 Objective: To investigate the dosage, method and efficacy of magnesium sulfate in the treatment of intractable epilepsy. Methods: The treatment group, 72 cases, with 25% magnesium sulfate 10mL intravenous infusion, or 16.5% magnesium sulfate 10mL orally. Control group of 36 patients given conventional antiepileptic drugs, carbamazepine or phenytoin plus phenobarbital or clonazepam with γ aminobutyric acid and other treatment. Results: The effective rate was 87.5% in the treatment group and 44.4% in the control group. The difference between the two groups was statistically significant (P <0.01). Conclusion: Magnesium sulphate combined with first-line anti-epileptic drugs for refractory epilepsy is simple and has good results