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自噬现象广泛存在于真核细胞中,是细胞的一种自我保护机制。这类分解代谢过程发生在细胞内,进化上具有高度保守性,在多种疾病及生命进程中发挥着重要作用。Sirtuin1(SIRT1)是一种组蛋白去乙酰化酶,具有烟酰胺腺嘌呤二核苷酸(NAD+)依赖性,在细胞生存、衰老、凋亡和代谢等生物学过程中扮演着重要角色。近年来,SIRT1与自噬的关系受到越来越多的关注,且SIRT1被证明与肿瘤的发生发展密切相关。探索SIRT1和自噬间的联系以及SIRT1介导的细胞自噬在肿瘤中的作用,有助于对肿瘤的发生发展机制展开进一步的探索。本文对肿瘤中SIRT1与自噬的作用关系及机制作以综述,希望能够为肿瘤的深入研究及新型靶向药物的研制提供新思路。
Autophagy is widespread in eukaryotic cells and is a self-protection mechanism of cells. Such catabolic processes occur intracellularly and are highly conserved in evolution and play an important role in various diseases and life processes. Sirtuin1 (SIRT1) is a histone deacetylase that has nicotinamide adenine dinucleotide (NAD +) dependence and plays an important role in the biological processes of cell survival, aging, apoptosis and metabolism. In recent years, the relationship between SIRT1 and autophagy has received more and more attention, and SIRT1 has been proved to be closely related to tumorigenesis. Exploring the relationship between SIRT1 and autophagy and the role of SIRT1-mediated autophagy in the tumor may help to further explore the mechanism of tumorigenesis and progression. This review summarizes the roles and mechanisms of SIRT1 and autophagy in cancer, and hopes to provide new ideas for the further study of tumors and the development of novel targeted drugs.