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目的：探讨胃癌ｃ－ｍｙｃ癌基因的表达及其与幽门螺杆菌（Ｈｐ）感染的关系。方法：应用逆转录ＰＣＲ（ＲＴ－ＰＣＲ）法检测６９例胃癌活检组织中ｃ－ｍｙｃ扩增。结果：胃癌癌区和癌旁组织ｃ－ｍｙｃ的阳性表达为６３．７７％和５０．７２％，分别高于胃溃疡组（Ｐ＜０．０１）；ｃ－ｍｙｃ表达在不同癌组织类型之间无显著性差异（Ｐ＞０．０５）；Ｈｐ阳性胃癌的癌区和癌旁ｃ－ｍｙｃ阳性扩增率为７０．２％和５８．０％，分别高于Ｈｐ阴性胃癌（４２．０％和３１．０％，Ｐ＜０．０５）。结论：胃癌组织中ｃ－ｍｙｃ的异常表达与Ｈｐ感染有相关性
Objective: To investigate the expression of c-myc oncogene in gastric cancer and its relationship with Helicobacter pylori (Hp) infection. METHODS: Reverse transcription PCR (RT-PCR) was used to detect c-myc amplification in 69 cases of gastric cancer biopsies. RESULTS: The positive expression of c-myc was 63.77% and 50.72% in gastric cancer and paracancerous tissues respectively, which was higher than that in gastric ulcer group (P<0.01). The expression of c-myc was different in different types of cancer tissues. There was no significant difference between the two groups (P>0.05). The c-myc-positive amplification rate in Hp-positive gastric cancer and adjacent cancer was 70.2% and 58.0%, respectively, higher than that of Hp-negative gastric cancer (42.0). % and 31.0%, P<0.05). Conclusion: Abnormal expression of c-myc in gastric cancer is related to Hp infection