论文部分内容阅读
目的探讨坎地沙坦联合美托洛尔对原发性高血压患者左室肥厚的影响。方法择我院2009年6月-2011年6月原发性高血压患者100例分为观察组和对照组。两组患者均在试验前2周停服所有对血压有影响的药物。观察组患者服用坎地沙坦,80mg/d,早晨服用,同时服用美托洛尔,每次12.5-50mg,2次/d。对照组患者单独服用美托洛尔,具体用法和用量同观察组。两组患者连续服用治疗6个月。采用超声心动图检查两组患者治疗前和治疗后左室肥厚改变情况。结果观察组治疗后收缩压和舒张压分别低于对照组治疗后,差异有统计学意义(P<0.05);观察组治疗后LVST、LVPWT、LVMI与对照组治疗后比较,差异有统计学意义(P<0.05)。结论坎地沙坦联合美托洛尔在控制血压同时能够显著改善原发性高血压患者左室肥厚,疗效显著,值得借鉴。
Objective To investigate the effect of candesartan and metoprolol on left ventricular hypertrophy in patients with essential hypertension. Methods Select our hospital June 2009 -2011 June 100 cases of essential hypertension patients were divided into observation group and control group. Two groups of patients were stopped 2 weeks before the test all the blood pressure of drugs. Patients in the observation group were given candesartan 80 mg once daily in the morning while taking metoprolol 12.5 to 50 mg twice daily. Patients in the control group took metoprolol alone, with the same usage and dosage as the observation group. Two groups of patients taking continuous treatment for 6 months. Echocardiography was used to examine changes in left ventricular hypertrophy before and after treatment in both groups. Results After treatment, systolic blood pressure and diastolic blood pressure were lower in the observation group than those in the control group (P <0.05). The LVST, LVPWT and LVMI in the observation group after treatment were significantly lower than those in the control group (P <0.05). Conclusions Candesartan combined with metoprolol can significantly improve left ventricular hypertrophy in patients with essential hypertension while controlling blood pressure, which is worthy of reference.