人乳头瘤病毒(HPV)E2蛋白一直被认为是E6/E7的转录抑制因子与肿瘤抑制因子。近年研究发现,在HPV所致细胞转化过程中,E2蛋白与细胞有丝分裂检测点相互作用,影响Cdc20、Skp2和APC/C等活性,涉及纺锤体组装检测点,关系到细胞基因的稳定性。由于E2蛋白可能在HPV致癌中具有推动作用,因而有望成为防治高危型HPVs所致肿瘤的一个新靶点。 Human papillomavirus (HPV) E2 protein has long been recognized as a transcriptional repressor and tumor suppressor of E6 / E7. In recent years, it has been found that during the process of HPV-induced cell transformation, the E2 protein interacts with mitotic detection sites and affects the activities of Cdc20, Skp2 and APC / C, as well as spindle assembly test sites, which is related to the stability of cellular genes. Because E2 protein may have a promoting role in HPV carcinogenesis, it is expected to become a new target for prevention and treatment of tumors caused by high-risk HPVs.