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柴油机颗粒物遗传毒性的研究在国际上已广泛开展,近年的研究表明它具有致基因突变的作用以及对 DNA 和染色体损伤的作用;动物长期吸入柴油机颗粒物可导致其肺癌发生率的增加。另外,对职业接触人群的流行病学调查得到有限的证据表明接触柴油机颗粒物与接触人群肺癌的发生有一定的关系。本文综述该方面研究的一些进展,并对其存在的一些问题进行了讨论。
In recent years, studies have shown that it has the role of gene mutation and DNA and chromosomal damage; long-term inhalation of diesel particulate matter can lead to an increase in the incidence of lung cancer in diesel particulate matter. In addition, there is limited evidence from epidemiological surveys of occupationally exposed populations that there is a relationship between exposure to diesel particulates and the development of lung cancer in exposed populations. This article reviews some of the progress made in this area and discusses some of its problems.