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目的:研究石菖蒲挥发油和水溶性成分对士的宁致癫痫小鼠脑组织SOD、LPO、NO的影响。方法:石菖蒲挥发油和水溶性成分灌胃小鼠用士的宁造成癫痫模型测定3 d后,小鼠脑组织SOD、LPO、NO的含量。结果:挥发油组,水提液组能增加小鼠脑组织SOD含量;挥发油组,水提液组、去油水煎液组能显著降低脑内LPO水平,除去油水煎液低剂量组外,其余各组均有降低脑内NO的作用。结论:实验结果提示活跃的自由基反应可能参与了癫痫的发病,石菖蒲挥发油和水溶性成分能有效清除自由基、阻止过氧化物形成,减少NO的神经毒性,对脑细胞具有良好的保护作用。
Objective: To study the effects of the volatile oil and water-soluble components of Acorus tatarinowii on SOD, LPO and NO in brain tissue of strychnine-induced epilepsy mice. METHODS: The contents of SOD, LPO, and NO in brain tissue of mice were determined 3 days after intragastric administration of strychnine to epilepsy model mice. Results: The volatile oil group and water extract group can increase SOD content in the brain; the volatile oil group, water extract group and deoiled decoction group can significantly reduce the level of LPO in the brain, and remove the low dose group of oil and water decoction. Both groups had the effect of reducing NO in the brain. Conclusion: The experimental results suggest that the active free radical reaction may be involved in the epileptogenesis. The volatile oil and water-soluble components of I. safrole can effectively scavenge free radicals, prevent peroxide formation, reduce the neurotoxicity of NO, and have a good protective effect on brain cells. .