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目的:探讨持续性心房颤动患者的血脑钠素(BNP)水平的改变及其与肾素血管紧张素醛固酮系统的关系。方法:对108例符合入选标准的住院患者分为持续性心房颤动组(55例)和对照组(53例),对2组患者的血BNP、肾素、血管紧张素Ⅱ、醛固酮水平进行检测,并行经胸超声心动图检查,测量左心房前后径。结果:2组血BNP分别为(79.65±16.23)μg/L、(50.12±15.97)μg/L(均P<0.01),多元线性逐步回归分析表明:左房内径、血管紧张素Ⅱ浓度是高血BNP水平的独立预测因素。结论:持续性心房颤动患者血BNP水平明显升高,与心房颤动患者的结构重构及肾素血管紧张素醛固酮系统密切相关。
Objective: To investigate the changes of blood brain natriuretic peptide (BNP) level in patients with persistent atrial fibrillation and its relationship with renin angiotensin aldosterone system. Methods: A total of 108 inpatients eligible for inclusion in the study were divided into two groups according to their duration of atrial fibrillation (55 cases) and control group (53 cases). Blood BNP, renin, angiotensin Ⅱ and aldosterone were measured in two groups , Parallel transthoracic echocardiography to measure the anteroposterior diameter of the left atrium. Results: The BNP levels of the two groups were (79.65 ± 16.23) μg / L and (50.12 ± 15.97) μg / L respectively (all P <0.01). Multiple linear stepwise regression analysis showed that the left atrial diameter and the concentration of angiotensin Ⅱ were high Independent predictors of blood BNP levels. CONCLUSION: The blood BNP level in patients with persistent atrial fibrillation is significantly elevated, which is closely related to the structural remodeling and renin-angiotensin aldosterone system in patients with atrial fibrillation.