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利用基因重组人白细胞介素３（ｒｈＩＬ－３）研究了１３例急性髓性白血病（ＡＭＬ）细胞体外对阿糖胞苷（Ａｒａ－Ｃ）的敏感性。结果，Ａｒａ－Ｃ对ＡＭＬ细胞的杀伤在不同的病例之间差异较大；在ｒｈＩＬ－３存在下，Ａｒａ－Ｃ对ＡＭＬ细胞的杀伤明显增强（Ｐ＜０．００１）。ＡＭＬ细胞对ｒｈＩＬ－３的反应具有异质性。探讨了ｒｈＩＬ－３与化疗药物联合用于治疗ＡＭＬ的可能性。
Thirteen cases of acute myeloid leukemia (AML) cells were studied for their sensitivity to Ara-C by using recombinant human interleukin-3 (rhIL-3). As a result, the killing effect of Ara-C on AML cells differed greatly among different cases; in the presence of rhIL-3, the killing effect of Ara-C on AML cells was significantly enhanced (P <0.001). The response of AML cells to rhIL-3 is heterogeneous. The possibility of using rhIL-3 in combination with chemotherapeutic agents to treat AML was explored.