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一些研究显示,肺部炎症性疾病患者呼出气NO浓度升高。ARDS具有中性粒细胞(PMN)肺内聚集和损伤的炎症过程。因此,作者假设ARDS患者气道中NO浓度远高于非肺部炎症性疾病。 13例诊断明确需机械通气治疗的ARDS患者,记录其肺损伤严重度评分(LISS)、血压及血液动力学等指标。18例非吸烟者的心脏外科手术,进行气管插管患者,排除急、慢性呼吸系统疾病及心功能不全后作为对照组。所有病例及对照组均采用化学发光法测定呼出气NO浓度。结果表明:ARDS组平均呼出气NO浓度为1.13±0.4ppb,其中5例未检测到NO存在;对照组呼出NO浓度为5.5±0.8ppb,远高于ARDS组(P<0.0001)。呼出气NO浓度与LISS、氧合指数、肺血
Some studies have shown that patients with pulmonary inflammatory disease exhaled breath NO concentration. ARDS has the inflammatory process of neutrophil (PMN) lung aggregation and injury. Therefore, the authors hypothesized that NO concentrations in the airways of ARDS patients are much higher than non-pulmonary inflammatory diseases. Thirteen patients with ARDS diagnosed with mechanical ventilation were enrolled. The severity of lung injury (LISS), blood pressure and hemodynamic parameters were recorded. Twenty-eight non-smokers underwent heart surgery and endotracheal intubation, excluding acute and chronic respiratory diseases and cardiac insufficiency as controls. All cases and control group were measured by chemiluminescence NO concentration of exhaled breath. The results showed that the mean exhaled NO concentration was 1.13 ± 0.4 ppb in ARDS group, but no NO was detected in 5 cases. The NO level in control group was 5.5 ± 0.8 ppb, much higher than that in ARDS group (P <0.0001). Exhaled NO concentration and LISS, oxygenation index, pulmonary blood