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目的:研究清热祛痛搽剂对尿酸钠诱导大鼠急性痛风性关节炎(GA)模型的治疗作用。方法:取45只大鼠,按体重随机分成5组。模型对照组,造模后按时间点涂等容积赋形剂;阳性药吲哚美辛组(4.5×10-3g·kg-1),于造模前1 h灌胃给药(10 mL·kg-1);清热祛痛搽剂高剂量组(0.91 g·kg-1)、中剂量组(0.46 g·kg-1)、低剂量组(0.23 g·kg-1),于造模后立即涂药(0.1 mL/只),并于致炎后6,12,24,48 h检测大鼠踝关节容积。结果:清热祛痛搽剂高、中、低剂量在致炎后各时间点均能不同程度的抑制尿酸钠所致大鼠踝关节疼痛,减轻肿胀程度,降低步态评分,与模型对照组比较差异有显著性(P<0.05)。结论:清热祛痛搽剂对尿酸钠引起的痛风性关节炎症有较好的治疗作用。
Objective: To study the therapeutic effect of Qingre Qutong liniment on sodium urate induced acute gouty arthritis (GA) model in rats. Methods: 45 rats were randomly divided into 5 groups according to body weight. The model control group was given the same volume of excipients as time points after modeling. The positive drug indometacin group (4.5 × 10-3g · kg-1) (0.91 g · kg-1), middle dose group (0.46 g · kg-1) and low dose group (0.23 g · kg-1) Immediately applied drug (0.1 mL / only), and the rat ankle volume at 6,12,24,48 h after inflammation. Results: Qingre Quyu Tong liniment at high, medium and low doses can inhibit uric acid-induced ankle joint pain, relieve swelling and reduce gait scores to different degrees at various time points after inflammation, compared with the model control group The difference was significant (P <0.05). Conclusion: Qingre Qushi Tong liniment on uric acid-induced gout arthritis have a better therapeutic effect.