自从X线照像的技术问世后,已开始注意到放射线对于血管形态学引起的改变。早在1899年Gassman就报道了放射性皮炎中的血管损伤,血管内皮肿胀、增生、并向管腔内形成突起。1937年Windholz观察到内膜高度增生伴有动脉的部分闭锁和静脉的完全性闭锁。以后,Warren又观察到照射野 Since the advent of radiographic techniques, attention has been paid to the changes that radiation causes to vascular morphology. As early as 1899 Gassman reported vascular damage in radiodermatitis, swelling of the vascular endothelium, hyperplasia, and the formation of protrusions in the lumen. 1937 Windholz observed intimal hyperplasia with arterial partial occlusion and complete closure of the vein. Warren later observed the field of exposure