近来免疫接种率高的人群中的麻疹爆发进一步强调了麻疹疫苗免疫失败是消灭麻疹的一个障碍。作者用汇总分析法来估计继发性麻疹疫苗免疫失败率（即疫苗诱导血清阳转后发生的临床麻疹）。 作者从1411项研究中选出125项相关研究。从这些研究中发现10项研究有计算合并的继发性免疫失败率的详尽资料。作者在合并前作了齐性检验。 尽管严重的不均匀性阻碍这些研究资料汇总为单一组群,但这些研究可分为三个均匀组群来作汇总分析。A组研究为灭活疫苗组,B和C组均为活疫苗组。A、B、C组的继发性麻疹疫苗免疫失败率分别为23％、4.8％～10％和0。B组与C组相比,有较高的免疫失败率,且难以从缺乏免疫记录,12月龄前免疫,非北美现场研究和疫苗生产商这几方面进行解释。而C组所有观察者都在 The recent outbreak of measles in populations with high immunization rates further underscores the immunological failure of measles vaccine as an impediment to measles elimination. The authors used pooled analysis to estimate the rate of secondary immunodeficiency (the clinical measles that occurs after the vaccine induces seroconversion). The authors selected 125 related studies from 1,411 studies. From these studies, 10 studies were found to have exhaustive data for calculating the combined rate of secondary immune failure. The author made a homogeneous test before the merger. Although severe inhomogeneities prevent these studies from being aggregated into a single cohort, these studies can be grouped into three cohort clusters for pooled analysis. Group A was inactivated vaccine group, group B and C were live vaccine group. The failure rates of secondary measles vaccine in groups A, B and C were 23%, 4.8% -10% and 0%, respectively. Group B has a higher rate of immune failure compared with Group C and is difficult to interpret in terms of lack of immunization records, immunizations prior to 12 months of age, non-North American field studies and vaccine manufacturers. While all observers in group C are there