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观察大黄素（Ｅｍｄ）和番泻甙Ａ（ＳｅｎＡ）对ＮＥ和高Ｋ＋诱导的兔主动脉条（ＲＡ）收缩作用的影响。结果表明，小剂量大黄素（１８．５μｍｏｌ·Ｌ－１）和番泻甙Ａ均可使ＮＥ和高Ｋ＋诱导的ＲＡ收缩的量效曲线左移，其作用原理可能与钙激动作用有关。大剂量大黄素（９２．５μｍｏｌ·Ｌ－１）抑制ＲＡ收缩作用，量效曲线右移，其作用可能与大黄素络合游离Ｃａ２＋作用有关。
To observe the effects of Emd and SenA on NE and K + -induced contractions of aortic strips (RA) in rabbits. The results showed that small dose of emodin (18.5μmol·L-1) and sennoside A can shift the dose-effect curve of NE and high K + -induced RA contraction to the left, and its action principle may be related to calcium activation. High dose of emodin (92.5μmol·L-1) inhibited the contractile effect of RA and the dose-response curve shifted to the right, which may be related to the complexation of free Ca2 + by emodin.