论文部分内容阅读
[目的]比较番茄汁和单体番茄红素对镉中毒小鼠抗氧化酶活力影响的差异。[方法]小鼠饲喂CdCl2、番茄红素或不同浓度番茄汁,4周后处死,测定肝、肾镉含量,测血清尿素氮(BUN)及谷丙转氨酶(ALT)的含量,测定血、肝、肾超氧化物岐化酶(SOD)活性、丙二醛(MDA)的含量、谷胱甘肽过氧化物酶(GSH-Px)的活力。[结果]与染镉组相比,番茄红素、番茄汁可促进肝、肾镉的排出,降低BUN、ALT的含量,降低血、肝、肾MDA的含量,使SOD、GSH-PX的活力恢复,以上各指标中,番茄汁随着浓度增大作用加强,低剂量组的作用虽比番茄红素组差,中剂量组的作用与番茄红素组相比无差别,高剂量组的作用比番茄红素组强。[结论]番茄汁对镉中毒小鼠肝、肾损伤的保护作用强于番茄红素,这可能与番茄红素和果汁中的其他植物化学物质发挥协同作用有关。
[Objective] To compare the effects of tomato juice and monomeric lycopene on the antioxidant enzyme activities of cadmium poisoning mice. [Methods] The mice were fed with CdCl2, lycopene or different concentrations of tomato juice. After 4 weeks, the mice were sacrificed. The content of liver and kidney cadmium, the levels of serum urea nitrogen (BUN) and alanine aminotransferase (ALT) Liver and kidney superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, glutathione peroxidase (GSH-Px) activity. [Result] Lycopene and tomato juice could promote the excretion of liver and kidney cadmium, reduce the content of BUN and ALT, and reduce the contents of MDA in blood, liver and kidney, and the activities of SOD and GSH-PX Recovery, the above indicators, tomato juice with the role of increasing concentration, although the role of low-dose group than the lycopene group, the role of medium-dose group compared with lycopene group no difference, the role of high-dose group Stronger than lycopene group. [Conclusion] The protective effect of tomato juice on liver and kidney injury in mice with cadmium poisoning is stronger than that of lycopene, which may be related to the synergistic effect of other phytochemicals in lycopene and fruit juice.