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目的:探讨西宁地区老年慢性心衰患者血浆超敏C反应蛋白水平、脑钠肽浓度及左心室EF值与心功能不全分级相关性并分析其临床意义。方法:选择65例,年龄均大于65岁的慢性心衰患者,依据NYHA分级,分为两组,心功能(Ⅰ~Ⅱ)级组,心功能(Ⅲ~Ⅳ)级组,分别测定超敏C反应蛋白水平,脑钠肽的浓度,同时心脏彩超测定左心室EF值,分析其与心功能不全的相关性,进行统计学分析。结果:两组肽浓度及ET值超敏C反应蛋白水平、脑钠对照比较,差异有统计学意义(P<0.05),随着患者心功能加重,脑钠肽、超敏C反应蛋白水平呈逐渐上升趋势,而EF值逐渐呈下降趋势,左心室EF值与血浆超敏C反应蛋白及脑钠肽浓度成负相关(r<0),差异有统计学意义(P<0.05)。结论:联合测定心衰指标,对动态评估西宁老年慢性心力衰竭患者的心功能状态及治疗预防方面具有一定的参考价值。
Objective: To investigate the relationship between plasma hs-CRP level, concentration of brain natriuretic peptide and left ventricular EF in patients with chronic heart failure in the elderly in Xining and its clinical significance. Methods: Sixty-five patients with chronic heart failure older than 65 years old were divided into two groups according to the NYHA classification. The patients in group Ⅰ ~ Ⅱ and group Ⅲ ~ Ⅳ were divided into two groups: C-reactive protein level, brain natriuretic peptide concentration, while the left ventricular EF value measured by echocardiography, analysis of its association with cardiac dysfunction, statistical analysis. Results: There was a significant difference between the two groups in peptide concentration and ET hypersensitive C-reactive protein level and brain natriuretic peptide (P <0.05). With the increase of cardiac function, the levels of brain natriuretic peptide and high-sensitivity C-reactive protein (P <0.05). There was a negative correlation between plasma EF and C-reactive protein and brain natriuretic peptide (r <0). The difference was statistically significant (P <0.05). Conclusion: The combined determination of heart failure index can be used as a reference for the dynamic assessment of cardiac function and prevention and treatment of elderly patients with chronic heart failure in Xining.