In order to solve the constraint satisfied problem in the genetic algorithm, the partheno-genetic algorithm is designed. And then the schema theorem of the partheno-genetic algorithm is proposed to show that the high rank schemas at the subsequent generation decrease exponentially even though its fitness is more optimal than the average one in the population and the low rank schemas at the subsequent generation increase exponentially when its fitness is more optimal than the average one in the population. In order to overcome the shortcoming that the optimal high rank schema can be deserted arbitrarily, the HGA (hybrid partheno-genetic algorithm) is proposed, that is, the hill-climbing algorithm is integrated to search for a better individual. Finally, the results of the simulation for facility layout problem and no-wait schedule problem are given. It is shown that the hybrid partheno- genetic algorithm is of high efficiency. And then the schema theorem of the partheno-genetic algorithm is proposed to show that the high rank schemas at the subsequent generation decrease exponentially even though its fitness is more optimal than the average one in the population and the low rank schemas at the subsequent generation increase exponentially when its fitness is more optimal than the average one in the population. In order to overcome the average one in the population. The proposed algorithm is integrated to search for a better individual. Finally, the results of the simulation for facility layout problem and no-wait schedule problem are it is shown that the hybrid partheno-genetic algorithm is of high efficiency.