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目的 探讨新生儿缺血缺氧性脑病(HIE)脑脊液(CSF)环磷酸腺苷(cAMP)变化及其临床意义。方法 采用法国:Immunotech公司提供的125I-cAMP放免药盒对86例HIE患儿进行脑脊液cAMP。结果 中、重度HIE组CSI-cAMP值较非HIE组明显降低,有显著差异(P<0.05);重度HIE患儿CSI-cAMP值较轻、中度患儿降低,差异具有显著性(P<0.05);恢复期较急性期CSF-cAMP值都有所升高,但无显著差异。结论 HIE时CSF-cAMP降低,病情愈重,降低愈明显。CSF-cAMP测定可作为HIE患儿判断病情的辅助指标。
Objective To investigate the changes of cyclic adenosine monophosphate (cAMP) in cerebrospinal fluid (CSF) of neonatal hypoxic-ischemic encephalopathy (HIE) and its clinical significance. Methods Cerebrospinal fluid cAMP was detected in 86 children with HIE using 125I-cAMP radiopharmaceutical kit from France: Immunotech. Results In the severe HIE group, the CSI-cAMP value was significantly lower than that in the non-HIE group (P <0.05). The CSI-cAMP value was lower in severe HIE children and lower in moderate HIE children, with significant difference (P < 0.05). The CSF-cAMP value in recovery phase was higher than that in acute phase, but there was no significant difference. Conclusions CSF-cAMP is decreased in HIE, the more serious the disease, the more obvious the reduction. CSF-cAMP determination can be used as HIE children to determine the condition of the auxiliary indicators.