研究了以抗组胺剂修饰的固体支撑双层类脂膜 (s BLM)分子器件体系对组胺的电化学传感行为 .结果表明 ,在s BLM膜中镶嵌抗组胺剂 ,体系对组胺的电化学响应强烈 ,并随着组胺浓度的增加而加大 ,这主要是由于组胺与抗组胺剂的特异性对抗效应引起的 .在接近通常的生理条件下 (pH =7.5 ) ,响应电流与组胺的浓度在 3.0～ 6 0 .0 μg/L呈良好的线性关系 ,相关系数为 0 .9878,表现出较高的灵敏度、选择性及良好的稳定性 .该体系可以在 - 2 0 0mV下用伏安法检测组胺的浓度 ,获得高稳定性和低检出限量的电化学生物传感器 The electrochemical sensing behavior of histamine with sBLM molecular device system modified by antihistamine was studied.The results showed that anti-histamine was immobilized on s BLM membrane, The electrochemical response of the amine is strong and increases with increasing histamine concentration, which is mainly due to the specific antagonistic effect of histamine and antihistamine.Under nearly normal physiological conditions (pH = 7.5) , The response current and the histamine concentration in the 3.0 ~ 600 μg / L showed a good linear relationship, the correlation coefficient of 0.9878, showing higher sensitivity, selectivity and good stability of the system can be - 200mV voltammetric detection of histamine concentration, high stability and low detection limit of the electrochemical biosensor