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In 1970,a gastric adenocarcinoma patient withincreased alpha fetoprotein(AFP)in his serum andliver metastatic tumor was reported by Bourreilile et al.At that time,it was realized that a gastric adenocarcinomacould produce AFP.In 1985,Ishikura et al reported ahepatocellular carcinoma(HCC)-like differentiation in aprimary gastric tumor and first proposed the conceptionof a“hepatoid carcinoma”.Subsequent documentation ofthis unique histopathologic feature has been made in
In 1970, a gastric adenocarcinoma patient withincreased alpha fetoprotein (AFP) in his serum and liver metastatic tumor was reported by Bourreilile et al. At that time, it was realized that a gastric adenocarcinoma produce aFP. In 1985, Ishikura et al reported ahepatocellular carcinoma HCC) -like differentiation in aprimary gastric tumor and first proposed the conception of a “hepatoid carcinoma.” Subsequent documentation of unique unique histopathologic features has been made in