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目的：通过对1058例大肠癌的临床病理学研究，分析其病理改变、临床诊治与预后的关系。方法：用组织化学染色观察，临床以内镜诊断及外科手术治疗为主。结果：对于早期大肠癌（病理镜下定为粘膜内癌及粘膜下癌）临床上可以采取活检及电切或局部切除手术治疗。经随访，复发率为2．3％，而做扩大或联合手术时病死率高达13．7％。对于局部扩散者及累及肌层者，宜采取联合手术。联合方案包括：手术、放疗和化疗。其最终目标是改善远期效果。结论：对于大肠癌尽早发现作出明确诊断，即时采取正确手术治疗方案，患者生存率将大为提高，预后较好。
Objective: To analyze the pathological changes, clinical diagnosis, treatment and prognosis of 1058 cases of colorectal cancer. Methods: Observed by histochemical staining, the main clinical endoscopic diagnosis and surgical treatment. RESULTS: For early colorectal cancer (pathologically defined as intramucosal and submucosal), biopsy, or electroresection or local resection can be used. After follow-up, the recurrence rate was 2.3%, and the rate of death was 13.7% in the case of expansion or combined surgery. For local spreaders and those who are involved in the muscularis, joint surgery should be taken. The joint program includes: surgery, radiotherapy and chemotherapy. Its ultimate goal is to improve long-term results. Conclusion: For a clear diagnosis of early detection of colorectal cancer and immediate correct surgical treatment, the survival rate of patients will be greatly improved and the prognosis is better.