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咪康唑(Miconazole)为新型广谱抗真菌药,除片剂及注射剂外,外用常用霜剂、散剂。我院试用复方咪康唑点耳液,其主要成份为硝酸咪康唑及苯甲酸纳,以70%乙醇为溶媒,苯甲酸钠作为增溶剂,并与咪康唑有协同作用。我院临床应用五年来,普遍反映疗效优于硼酸乙醇液及麝香草酚乙醇液。硝酸咪康唑的含量测定,美国药典21版采用紫外分光光度法,本文利用双波长分光光度法可消除苯甲酸钠的干扰,并有简单快速的优点。
Miconazole (Miconazole) is a new broad-spectrum antifungal agent, in addition to tablets and injections, topical creams, powders. Our hospital trial compound miconazole point ear fluid, the main ingredients of miconazole nitrate and benzoic acid satisfied with 70% ethanol as a solvent, sodium benzoate as a solubilizer, and miconazole synergistic effect. Clinical application of our hospital over the past five years, the general effect is better than the boric acid ethanol solution and thymol ethanol solution. Determination of miconazole nitrate content, the United States Pharmacopoeia 21 edition using UV spectrophotometry, dual wavelength spectrophotometry in this paper can eliminate the interference of sodium benzoate, and has the advantages of simple and quick.