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脂质体制备方法按照1965年Bangham首次发表的方法,取10ml豆磷脂的氯仿溶液(10mg/ml)及2ml胆固醇的氯仿溶液(5mg/ml)于旋转蒸发器40℃蒸发至干,加入盐酸氯洁霉素溶液20ml(1或5％),在温和搅拌下即形成MLV脂质体。临床用三种洗剂制备 1.氯洁霉素标准洗剂药物溶解于10％丙二醇及70％乙醇的混合液中。2.氯洁霉素洗剂-乳剂由2％Hostaphatkw 340N,2%Hostacerin,88％蒸馏水及防腐剂制成乳剂,药物溶液(5％)以1:4加入乳剂。3.氯洁霉素脂质体洗剂5％的药物混悬剂以1:4加入乳剂,使
Preparation of liposomes According to the first published by Bangham in 1965, 10 ml of chloroform solution of soya lecithin (10 mg / ml) and 2 ml of chloroform solution (5 mg / ml) were evaporated to dryness on a rotary evaporator at 40 ° C., Lincomycin solution 20ml (1 or 5%), with gentle stirring to form MLV liposomes. Clinical preparation of three kinds of lotion 1. Clindamycin standard lotion drug was dissolved in a mixture of 10% propylene glycol and 70% ethanol. 2. Clindamycin Lotion - Emulsion An emulsion was prepared from 2% Hostaphatkw 340N, 2% Hostacerin, 88% distilled water and a preservative. The drug solution (5%) was added to the emulsion at 1: 4. 3. Clindamycin liposome lotion 5% of the drug suspension to 1: 4 added to the emulsion