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目的：了解层粘连蛋白（ＬＮ）和Ⅳ型胶原在口腔粘膜鳞状细胞癌中的表达情况。方法：采用免疫组化之ＳＰＴＭ法对３０例口腔鳞状细胞癌，１０例正常口腔粘膜染色。结果：正常口腔粘膜基底膜ＬＮ和Ⅳ型胶原染色密度高，呈连续线状。鳞状细胞癌ＬＮ和Ⅳ胶原的染色密度。基底膜的连续性与肿瘤的分化程度呈负相关。结论：ＬＮ和Ⅳ型胶原的表达异常与肿瘤分化、浸润和转移有密切关系，可作为判断肿瘤预后的一项指标
Objective: To investigate the expression of laminin (LN) and collagen Ⅳ in oral squamous cell carcinoma. Methods: Immunohistochemical SPTM method in 30 cases of oral squamous cell carcinoma, 10 cases of normal oral mucosa staining. Results: Normal oral mucosa LN and type Ⅳ collagen staining density, continuous linear. Dyeing density of LN and Ⅳ collagen in squamous cell carcinoma. The continuity of basement membrane was negatively correlated with the degree of tumor differentiation. Conclusion: The abnormal expression of LN and type Ⅳ collagen is closely related to tumor differentiation, invasion and metastasis, which can be used as an indicator of tumor prognosis