建立稳定的树脂-牙本质混合层是提高修复体粘接耐久性的有效方法.交联剂对牙本质的生物改性可增强胶原的力学性能及抗酶解性,抑制脱矿进程并促进牙本质再矿化,具有预防龋齿以及改善粘接剂性能的临床价值.本文分类阐述不同交联剂对牙本质Ⅰ型胶原的生物改性作用.“,”Establishing a stable resin-dentin hybrid layer is an effective method to improve the adhesion durability of the restoration.The biomodification of dentin by cross-linkers can enhance the mechanical properties of collagen and resistance to enzymatic hydrolysis while,inhibiting the process of demineralization and promoting the remineralization of dentin,which has the potential clinical applicability of preventing dental caries and improving adhesive property.This review summarizes the biomodification of dentin type Ⅰ collagen by different cross-linkers.