多发性硬化 (MS)是神经学科的科研热点之一 ,至今虽无特效治疗 ,但多种新的有效治疗药物在临床和科研方面均取得了丰硕成果。本文综述了各型干扰素 (IFN)在多发性硬化病程中的作用机制 ,尤其是IFN - β对MS的治疗作用。并较完整的介绍了三种上市IFN制剂 (Betaseron、Avonex/Rebif和Roferon)的具体临床应用。 Multiple sclerosis (MS) is one of the hot research topics in neurology. So far there is no effective treatment, but many new and effective therapies have achieved great clinical and scientific results. This article reviews the mechanism of various types of interferon (IFN) in the course of multiple sclerosis, especially the therapeutic effect of IFN - β on MS. And a more complete introduction of the three listed IFN preparations (Betaseron, Avonex / Rebif and Roferon) for specific clinical applications.