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依托泊甙(鬼臼乙叉甙,VP16-213)具有广谱抗癌活性和相当高的治疗指数,尤其对早期扩散、预后恶劣的小细胞肺癌效果较好。但它的水中溶解度小、临床用药剂量大,有待改进剂型。本文将其制成脂质体,进行了较系统的制剂学研究,并探索其疗效和体内分布。首次应用三阶导数紫外分光光度法测定了VP16-213脂质体的含量,不受赋形剂干扰故毋须分离,回收率达99.87±1.87％。重点探讨了脂质体制备工艺、各种附加剂以及荷电性对包裹率的影响,结果表明,带
Etoposide (etoposide, VP16-213) has a broad spectrum of anticancer activity and a relatively high therapeutic index, especially for early-stage small cell lung cancer with poor prognosis. However, its solubility in water is small, a large dose of clinical medication needs to be improved dosage form. This article will be made into liposomes, conducted a more systematic formulation studies, and explore its efficacy and distribution in vivo. For the first time, the third derivative UV spectrophotometry was used to determine the content of VP16-213 liposomes without the interference of the excipients. The recovery rate was 99.87 ± 1.87%. The preparation of liposomes, the effects of various additives and chargeability on the encapsulation efficiency were discussed. The results showed that the