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硫酸头孢匹罗为第4代头孢菌素,临床效果好.综述了硫酸头孢匹罗适合工业化的2种合成方法,即以7-氨基头孢烷酸(7-ACA)为原料合成方法和以7-苯乙酰胺基-3-碘甲基头孢烷酸对甲氧基苄酯(GCLE)为原料合成方法.指出以7-氨基-3-乙烯基头孢烷酸(7-ACA)为原料合成方法成本低、反应速度快、产率高,更适合工业化生产,今后应继续对其工艺进行深入研究.“,”Cefpirome sulfate,one of the fourth generation cephalosporins, has good clinical effects. Two kinds of synthetic technologies of cefpirome sulfate were summaried,those were with 7-amino-cephalosporanic acid(7-ACA)as material and with 7- acetophenone amide-3- methyl iodide cephalosporanic acid p-methoxybenzyl ester(GCLE)as material. It was pointed out that the synthetic technology with 7-ACA as material had some characteristics of low cost, fast reaction speed, high yield and more suitable for industrial production, so the technology should be further studied.