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目的:探讨肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)基因和白细胞介素13(interleukin-13,IL-13)基因多态性与青岛地区汉族成人哮喘患者大鱼际掌纹特应征的相关性。方法:应用SNa Pshot方法对400例哮喘患者和200名正常对照的TNF-α基因的rs1799724,rs1800630,rs1799964和rs769178以及IL-13基因的rs2158177和rs1295687共6个多态位点的基因多态性进行检测。结果:TNF-α基因的rs1799724,rs1800630,rs1799964和rs769178以及IL-13基因的rs2158177和rs1295687的基因型频率在掌纹阴性组与掌纹阳性组间差异无统计学意义(P>0.05)。结论:未发现TNF-α基因和IL-13基因多态性与青岛地区汉族成人哮喘患者大鱼际掌纹特应征存在相关性。
Objective: To investigate the relationship between the gene polymorphisms of tumor necrosis factor-α (TNF-α) and interleukin-13 (IL-13) Correlation of extras. Methods: SNa Pshot method was used to detect polymorphisms of rs1799724, rs1800630, rs1799964 and rs769178 of TNF-α gene and rs2158177 and rs1295687 of IL-13 gene in 400 asthma patients and 200 normal controls. Test. Results: The frequencies of rs1799724, rs1800630, rs1799964 and rs769178 of TNF-α gene and rs2158177 and rs1295687 of IL-13 gene were not significantly different between palmprint negative group and palmprint positive group (P> 0.05). Conclusion: The polymorphisms of TNF-α gene and IL-13 gene were not found to be associated with the palpation of palpation in the major meiosis of adult patients with asthma in Han nationality in Qingdao.