DNA甲基化主要指DNA 5’胞嘧啶甲基化,引起基因表达异常。近几年研究发现,在癌细胞中,肿瘤抑制基因甲基化的发生率与肿瘤抑制基因突变或缺失发生的概率大致相等,均可导致肿瘤抑制基因功能的丧失[1]。在许多组织来源的肿瘤中,尤其是造血系统来源的肿瘤,例如骨髓增生异常综合征,基 DNA methylation mainly refers to DNA 5 ’cytosine methylation, causing abnormal gene expression. In recent years, the study found that in cancer cells, the incidence of tumor suppressor gene methylation and mutation or deletion of tumor suppressor gene approximately the same probability of occurrence, can lead to the loss of tumor suppressor gene function [1]. Among many tissue-derived tumors, especially those of hematopoietic origin, such as myelodysplastic syndrome