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CD14分为膜上CD14(mCD14)和可溶性CD14(sCD14)。mCD14分布在单核细胞等表面;sCD14存在于正常人和动物的血清中。编码CD14的基因已被克隆,该基因位于人5号常染色体长臂端5q23-q31。mCD14是一种55kDa糖蛋白,化学组成为糖基磷脂酰肌醇(GPI)—蛋白质,通过PI的磷脂部分与细胞膜连接;sCD14蛋白部分与mCD14基本相同,但不含PI部分,故分子量稍小,为48kDa。mCD14作为LPS受体,介导LPS对单核细胞等的刺激作用,sCD14也可与LPS结合,激活、损伤无mCD14的上皮细胞
CD14 is divided into membrane CD14 (mCD14) and soluble CD14 (sCD14). mCD14 distributed on the surface of monocytes; sCD14 exists in normal human and animal serum. The gene encoding CD14 has been cloned and is located on the 5q23-q31 long arm of human chromosome 5. mCD14 is a 55 kDa glycoprotein whose chemical composition is glycosylphosphatidylinositol (GPI) - a protein that is linked to the cell membrane via the phospholipid portion of PI. The sCD14 protein is partially identical to mCD14 but does not contain a PI moiety, , 48 kDa. As an LPS receptor, mCD14 mediates stimulation of LPS on monocytes, etc. sCD14 also binds to LPS, activating and damaging epithelial cells without mCD14