血栓素合成抑制及其受体的拮抗剂联合作用,要比单独作用强,可使血小板聚集明显抑制,出血时间延长。Ridogrel是能起到这两种功效的药物,其延长出血时间的作用比服用小或大剂量阿斯匹林者明显。本文以血浆β-血栓球蛋白(βTG)和血小板因子4(PF4)为指标,证明此药对有血小板功能亢进的病人有此双重作用。 21名患者年龄67～90岁,超声波和血管造影确诊为闭塞性动脉病,βTG升高(>25ng/ml,PF4小 Inhibition of thromboxane synthesis and its receptor antagonist combination, stronger than alone, can significantly inhibit platelet aggregation, prolonged bleeding time. Ridogrel is a drug that works both ways, with a significant effect of prolonging bleeding time compared with those taking small or large doses of aspirin. In this paper, plasma β-thromboglobulin (βTG) and platelet factor 4 (PF4) as an indicator that this drug has a dual role in patients with platelet hyperactivity. 21 patients aged 67 to 90 years, ultrasound and angiography diagnosed as occlusive arterial disease, βTG increased (> 25ng / ml, PF4 small