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目的 探讨左旋甲状腺素钠治疗小儿甲状腺功能减低症的疗效、安全性及合适的剂量。方法治疗组(简称L组)，用L-甲状腺素钠治疗(n=40)，对照组(简称T组)，用干甲状腺素片治疗(n=35)，观察临床表现，TSH，T3，T4及骨龄的变化。结果 两组4周症状缓解率有显著性差异，L组高于T组，(χ2=13.78，P<0.01)，TSH，T4 4周恢复时间对比，两组差异有显著性，L组高于T组，(χ2=24.75，P<0.05)，治疗组无1例出现高甲状腺素血症。结论 L-甲状腺素钠治疗小儿甲状腺功能减低症，对脑发育的改善较传统方法明显，且副作用少，值得临床推广使用。
Objective To investigate the efficacy, safety and appropriate dosage of levothyroxine for the treatment of hypothyroidism in children. Methods The treatment group (L group) was treated with L-thyroxine sodium (n = 40) and the control group (T group) with the treatment of dry thyroxine tablets (n = 35) T4 and bone age changes. Results There was a significant difference in remission rate between the two groups at 4 weeks. L group was higher than T group (χ2 = 13.78, P <0.01), and recovery time of TSH and T4 4 weeks was significant difference between the two groups T group (χ2 = 24.75, P <0.05). None of the treatment group had hypertocidemia. Conclusion L-thyroxine sodium treatment of children with hypothyroidism, the improvement of brain development than the traditional method is obvious, and less side effects, it is worth promoting the use of the clinic.