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目的探讨射频消融术与125I放射性粒子植入联合区域性灌注治疗胰腺癌的临床效果。方法将105例胰腺癌患者随机分为两组,对照组55例采用射频消融术治疗,观察组50例采用125I放射性粒子植入联合区域性灌注化学疗法治疗,比较两组的临床效果。结果术后观察组患者疼痛程度轻于对照组(P<0.01);术后所有患者均接受长期随访,对照组生存时间≤2年者35例(63.6%),3～4年者19例(34.5%),≥5年者1例(1.8%);观察组生存时间≤2年者17例(34.0%),3～4年者36例(72.0%),≥5年者7例(14.0%);观察组患者3～4年生存率高于对照组(P<0.01);5年以上生存率也高于对照组(P<0.05)。观察组患者并发症发生率低于对照组(P<0.05)。结论 125I放射性粒子植入联合区域性灌注化学疗法治疗胰腺癌效果明显,可提高患者生存率。
Objective To investigate the clinical effect of radiofrequency catheter ablation and 125I radioactive particle implantation combined with regional perfusion in the treatment of pancreatic cancer. Methods A total of 105 patients with pancreatic cancer were randomly divided into two groups. The control group was treated by radiofrequency catheter ablation, and the observation group was treated by 125I radioactive seed implantation combined with regional perfusion chemotherapy. The clinical effects were compared between the two groups. Results All the patients in the postoperative observation group had a lower degree of pain than the control group (P <0.01). All the patients were followed up for a long period of time. In the control group, 35 patients (63.6%) had survival time less than 2 years, 19 patients 34.5%), 1 case (≥ 1.8%) in ≥ 5 years, 17 cases (34.0%) in survival group ≤ 2 years, 36 cases (3-4.0%) in 3-4 years, %). The 3-year and 4-year survival rates of the observation group were higher than those of the control group (P <0.01). The 5-year survival rates were also higher than those of the control group (P <0.05). The complication rate in observation group was lower than that in control group (P <0.05). Conclusion 125I radioactive seed implantation combined with regional perfusion chemotherapy has obvious effect on pancreatic cancer and can improve the survival rate of patients.