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目的探讨神经节苷脂改善脑外伤后认知功能障碍的疗效。方法对2003年8月～2006年5月在我院住院治疗的60例脑外伤并认知功能障碍患者,以常规治疗为对照,进行随机双盲配对试验,观察神经节苷脂疗效并进行对比分析。伤后1周内给药,于用药前、用药后1周、2周、3周进行简易智能精神状态表(MMSE)评分和临床观察。结果神经节苷脂组与常规治疗组对比发现用药后第2、3周MMSE评分显著升高(P<0.05)。3周后神经节苷脂组认知功能障碍完全康复率为91.41%,显著高于常规治疗组的56.00%(P<0.05)。结论早期应用神经节苷脂对改善脑外伤后认知功能障碍是有较好疗效的。
Objective To investigate the efficacy of gangliosides in improving cognitive dysfunction after traumatic brain injury. Methods Sixty patients with traumatic brain injury and cognitive impairment who were hospitalized in our hospital from August 2003 to May 2006 were treated with routine treatment as control and randomized double-blind paired test to observe the effect of ganglioside and compare them analysis. Within 1 week after injury, MMSE score and clinical observation were performed before treatment, 1 week, 2 weeks and 3 weeks after treatment. Results Compared with the conventional treatment group, the MMSE score of the ganglioside group was significantly increased at the second and third weeks after treatment (P <0.05). After 3 weeks, the complete recovery rate of cognitive dysfunction in ganglioside group was 91.41%, which was significantly higher than that in conventional treatment group (56.00%, P <0.05). Conclusion Early application of gangliosides improves cognitive impairment after traumatic brain injury.