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肠出血性大肠杆菌(enterohemorrhagic Escherichia coli,EHEC)O157:H7是一种重要的肠道病原微生物,感染后可引发多种疾病,严重者可导致死亡。EHEC O157:H7通过III型分泌系统(TTSS)将其转位效应器蛋白质转位至宿主细胞,经一系列的信号传导过程介导与宿主细胞的“黏附与擦拭”(attaching and effacing,A/E)损伤。对EHECO157:H7III型分泌系统及其转位效应器蛋白质进行研究,可使我们进一步认识EHEC以及引起A/E损伤的病原菌的致病机理,丰富有关III型分泌系统和致病岛的知识。
Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is an important intestinal pathogenic microorganism that can cause various diseases after infection. In severe cases, it can cause death. EHEC O157: H7 translocates its translocator effector protein to host cells via the type III secretion system (TTSS), which leads to “attaching and effacing with host cells” via a series of signaling processes, A / E) Damage. Studying the EHECO157: H7III secretion system and its translocation effector proteins will allow us to further understand the pathogenesis of EHEC and pathogenic bacteria that cause A / E damage and enrich our knowledge of the type III secretion system and the pathogenic island.