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本实验观察了加胰岛素前后内皮素-1（ET－1）对WKY／SHR离体主动脉的作用，结果发现：（1）与WKY相比，SHR动脉对ET－1具有抵抗性，表现为在同样的ET－1浓度下，WKY动脉收缩而SHR动脉舒张；（2）胰岛素明显增强ET-1对正常动脉的收缩作用，最大增强效应可达50％；明显减弱ET-1对高血压动脉的舒张作用，最大拮抗程度可达100％。作者认为胰岛素对血管活性物质的增敏作用可部分解释胰岛素抵抗现象与高血压发病的密切关系。
In this study, the effect of endothelin-1 (ET-1) on isolated aorta of WKY / SHR was observed before and after adding insulin. The results showed that: (1) Compared with WKY, SHR arteries were resistant to ET- In the same concentration of ET-1, WKY arteries contracted and SHR arteries were dilated. (2) Insulin significantly enhanced the contractile effect of ET-1 on normal arteries, and the maximal enhancement effect was up to 50%. ET-1 significantly attenuated the hypertensive arteries Of the diastolic effect, the maximum degree of antagonism up to 100%. The authors believe that insulin sensitization of vasoactive substances may explain in part the close relationship between insulin resistance and the incidence of hypertension.