以豆腐果苷为原料,与取代苯甲酰肼反应生成中间体4-β-D-吡喃阿洛糖苷-苯甲醛取代苯甲酰腙(2a～2g),在溴作催化剂的条件下发生关环反应,合成了一系列豆腐果苷类似物3a～3g,所有化合物结构经IR,1H NMR以及MS谱得以证实.初步药理实验结果表明,化合物3a,3c,3f与豆腐果苷相比有更好的镇静活性。 Taking tofuin as raw material and reacting with substituted benzoic hydrazide to produce intermediate 4-β-D-allylidene glycoside-benzaldehyde substituted benzoyl hydrazone (2a ~ 2g), under the condition of bromine as catalyst A series of tocopherol analogs 3a ~ 3g were synthesized by ring closure reaction, and the structures of all the compounds were confirmed by IR, 1H NMR and MS spectra. The results of preliminary pharmacological experiments showed that compounds 3a, 3c, 3f Better calming activity.