本文报告应用甲基强的松龙冲击疗法治疗小儿难治性肾病综合征16例,其中14侧冲击治疗前口服强的松每日2mg/kg×8周,无明显疗效;另2例为勤复发型原发性肾病,此次入院后即进行冲击治疗。冲击用甲基强的松龙,剂量为每次15mg/kg或每次20mg/kg。治疗结果9例完全缓解,6例部分缓解,仅1例无效。此结果表明甲基强的松龙冲击治疗难治性肾病综合征有显著疗效。 This article reports the application of methylprednisolone impact therapy in children with refractory nephrotic syndrome in 16 cases, of which 14 side effects of oral prednisone oral treatment of daily 2mg / kg × 8 weeks, no significant effect; the other two cases of ground-based Recurrent primary kidney disease, the impact of treatment after admission. Impact with methylprednisolone, each dose of 15mg / kg or 20mg / kg each time. Treatment of 9 cases of complete remission, 6 cases of partial remission, only 1 case of ineffective. This result shows that methylprednisolone impact treatment of refractory nephrotic syndrome has a significant effect.